Interferons are critical for a mother’s immune response during Zika infection, but could have detrimental impacts on placental and fetal development, according to new research.
The exact mechanism(s) linking fetal Zika infection and congenital microcephaly remains unclear, however, an international team of researchers have now identified a possible role for unfolded protein responses in this process.
Results for Phase I Zika vaccine trials have recently demonstrated that both a gene-based and an inactivated virus vaccine appear to be safe and immunogenic.
Researchers from Yale University have suggested that the immune response may be responsible for neurological complications in Zika infection, as opposed to the virus itself.
Researchers have demonstrated that mice previously infected with dengue have protection against Zika virus that appears to be conferred by cytotoxic T cells.
A new DNA-based Zika vaccine, GLS-5700, has been reported as safe and immunogenic in Phase I trial, according to new research.
Researchers have discovered that antibodies taken from dengue virus infected individuals are effective in treating Zika infection – a closely related flavivirus – in rodents.
Research in mice and cell lines has demonstrated the potential of Zika virus to target and kill glioblastoma stem cells, suggesting a possible new treatment for this brain cancer.
Characterizing the ligand-binding landscape of Zika NS3 helicase-promising lead compounds as potential inhibitors
This study from Future Virology, aims to provide insight into the binding features of the ATPase and ssRNA sites of the NS3 helicase.
Researchers from Washington University of St. Louis have developed a proof-of-concept test that can rapidly detect the presence of Zika virus in blood, without the need for refrigeration.